Description

Palonosetron is a highly potent and selective second-generation 5-HT3 receptor antagonist. This compound is valued for its superior efficacy and extended duration of action in preventing nausea and vomiting. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing antiemetic therapies. Our supply ensures high purity and reliable consistency for critical pharmaceutical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV).
• Oncology Supportive Care: A key component in antiemetic regimens for patients undergoing highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC).
• Postoperative Nausea and Vomiting (PONV) Prevention: Used in the formulation of medications aimed at preventing nausea and vomiting following surgical procedures.
• Drug Development & Research: Serves as a reference standard and building block in pharmacological research and the development of new therapeutic entities.
• Formulation Development: Utilized in the R&D of various dosage forms, including lyophilized powders for injection and potential oral formulations.

Basic Information

Product Name	Palonosetron
CAS No.	135729-60-1
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Palonosetron Hydrochloride; (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; RS-25259-197; Aloxi (Brand Name); Onicit; Paloxi; Palosetron
EINECS	Contact for details

Quality Control

Our Palonosetron is manufactured under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with your stringent API specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.