Description

Palonosetron CAS NO 135729-56-5 is a highly potent and selective second-generation 5-HT₃ receptor antagonist. This compound is critical for its superior efficacy and extended duration of action in managing nausea and vomiting. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing advanced antiemetic therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable and oral formulations for the prevention of chemotherapy-induced nausea and vomiting (CINV).
• Postoperative Nausea and Vomiting (PONV) Prophylaxis: Key component in medications designed to prevent nausea following surgical procedures.
• Drug Development & Research: Serves as a reference standard and building block in pharmacological research and the development of new antiemetic drugs.
• Formulation Studies: Used in stability testing, excipient compatibility studies, and the development of novel drug delivery systems.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of branded palonosetron hydrochloride medications.

Basic Information

Item	Details
Product Name	Palonosetron
CAS No.	135729-56-5
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Palonosetron Hydrochloride; (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; Aloxi® (Brand Name); RS-25259; RS-25259-197; BRL-43694A; Palonosetronum; Palonosetron HCl
EINECS	Contact for details

Quality Control

Our Palonosetron is manufactured under strict quality management systems. We provide material that meets or exceeds pharmaceutical-grade standards, with typical purity levels ≥98.5% (HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and residual solvents. Specifications are aligned with ICH guidelines and can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.