Description

(19E)-19,20-Didehydro-1-Demethyl-17-Oxoajmalan-16-Carboxylic Acid Methyl Ester is a high-purity, semi-synthetic ajmaline alkaloid derivative with significant importance in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and reference standard for the development of novel cardiovascular and antiarrhythmic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) who require high-fidelity chemical building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex therapeutic alkaloids and specialized cardiovascular drugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Research: Employed in pharmacological studies to investigate ion channel modulation and cardiac electrophysiology.
• Process Chemistry: Serves as a pivotal intermediate in scaling up the production of ajmaline-related APIs under current Good Manufacturing Practice (cGMP) conditions.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to design and optimize new chemical entities with targeted biological activity.

Basic Information

Product Name	(19E)-19,20-Didehydro-1-Demethyl-17-Oxoajmalan-16-Carboxylic Acid Methyl Ester
CAS No.	135649-95-5
Molecular Formula	C21H24N2O3
Molecular Weight	352.43 g/mol
Synonyms	1-Demethyl-17-oxoajmalan-16-carboxylic acid methyl ester, (19E)-19,20-didehydro-; Methyl (19E)-19,20-didehydro-1-demethyl-17-oxoajmalan-16-carboxylate; 17-Oxo-1-demethylajmalan-16-carboxylic acid methyl ester, 19,20-didehydro-; Ajmaline derivative, 1-demethyl-17-oxo-; 16-Carbonethoxy-19,20-didehydro-1-demethyl-17-oxoajmalan
EINECS	Contact for details

Quality Control

Our (19E)-19,20-Didehydro-1-Demethyl-17-Oxoajmalan-16-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and structural confirmation via spectroscopic methods (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support development projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.