Description

Se-(8-Azidoadenosyl)Selenomethionine is a specialized seleno-amino acid derivative that incorporates both an azido functional group and an adenosyl moiety. This unique molecular architecture makes it a critical reagent for advanced biochemical research, particularly in the study of selenoprotein synthesis, enzyme mechanisms, and metabolic labeling. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on selenium biochemistry, proteomics, and the development of novel therapeutic agents.

Application

• Biochemical Research: A key precursor for studying the biosynthesis and function of selenoproteins and selenoenzymes.
• Metabolic Labeling: Used in pulse-chase experiments to track the incorporation of selenium into proteins via its metabolically active form.
• Click Chemistry Substrate: The azido group enables bioorthogonal "click" reactions (e.g., with alkynes) for labeling, pull-down assays, or imaging studies.
• Enzyme Mechanism Studies: Serves as a substrate analog to investigate the catalytic mechanisms of methionine adenosyltransferases and other methyltransferases.
• Pharmaceutical R&D: Employed in drug discovery programs targeting pathways involving selenium metabolism and methylation cycles.
• Proteomics: Facilitates the selective enrichment and identification of selenium-containing proteins in complex biological samples.

Basic Information

Product Name	Se-(8-Azidoadenosyl)Selenomethionine
CAS No.	135608-83-2
Molecular Formula	C15H21N9O5Se
Molecular Weight	502.35 g/mol
Synonyms	8-Azido-5'-deoxy-5'-(selenomethylthio)adenosine; 8-N3-Se-adenosyl-L-selenomethionine; Azido-Se-adenosylmethionine; Se-(8-Azidoadenosyl)-L-selenomethionine; 8-Azido-SeAM; 8-Azido-5'-[(selenomethyl)sulfonio]-5'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our Se-(8-Azidoadenosyl)Selenomethionine is produced under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.