Description

1-(Chloro-1-Pyrrolidinylmethylene)Pyrrolidinium Hexafluorophosphate is a highly reactive organophosphorus reagent, primarily valued as a potent coupling agent in peptide synthesis and other organic transformations. Its core value proposition lies in its ability to efficiently activate carboxylic acids, facilitating the formation of amide bonds under mild conditions with minimal racemization. This makes it a critical component for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing peptide-based therapeutics and complex organic molecules.

Application

• Peptide Synthesis: As a key coupling reagent (often compared to HATU or HBTU) for solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Pharmaceutical Intermediate Manufacturing: For the synthesis of active pharmaceutical ingredients (APIs) requiring high-purity amide bond formation.
• Bioconjugation: Facilitating the linkage of peptides, proteins, or other biomolecules to carriers, dyes, or solid supports.
• Organic Chemistry Research: Used in academic and industrial R&D labs for constructing complex amides, esters, and other derivatives from carboxylic acids.
• Ligand and Catalyst Synthesis: In the preparation of specialized phosphorous-containing ligands or organocatalysts.

Basic Information

Product Name	1-(Chloro-1-Pyrrolidinylmethylene)Pyrrolidinium Hexafluorophosphate
CAS No.	135540-11-3
Molecular Formula	C10H17ClF6N2P
Molecular Weight	354.67 g/mol
Synonyms	Chloro(1-pyrrolidinylmethylene)pyrrolidinium hexafluorophosphate; Pyrrolidinium, 1-[chloro(1-pyrrolidinyl)methylene]-, hexafluorophosphate(1-); (1-Chloro-1-pyrrolidinylmethylene)pyrrolidinium hexafluorophosphate; Common peptide coupling reagent; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 1-(Chloro-1-Pyrrolidinylmethylene)Pyrrolidinium Hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in polar aprotic solvents (e.g., DMF, DMSO, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.