Description

10-Propargyl-5-Methyl-5-Deazaaminopterin Analog Of Folic Acid is a synthetic folate analog designed for advanced biochemical and pharmaceutical research. This compound matters as a potent and selective inhibitor of dihydrofolate reductase (DHFR), offering a crucial tool for studying folate metabolism and cell proliferation pathways. It is primarily needed by researchers and developers in the fields of oncology, enzymology, and medicinal chemistry for the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a high-affinity inhibitor in enzyme kinetics studies of dihydrofolate reductase (DHFR).
• Anticancer Research: Investigated as a potential lead compound for the development of novel chemotherapeutic agents targeting rapidly dividing cells.
• Medicinal Chemistry: Serves as a key intermediate or reference standard in the synthesis and optimization of new folate antagonist drugs.
• Cell Biology Studies: Employed to modulate intracellular folate pools and study the effects on DNA synthesis and cell cycle progression.
• Academic & Pharmaceutical R&D: A critical reagent for fundamental research into antifolate mechanisms and resistance.

Basic Information

Product Name	10-Propargyl-5-Methyl-5-Deazaaminopterin Analog Of Folic Acid
CAS No.	135423-85-7
Molecular Formula	C21H23N7O5
Molecular Weight	453.45 g/mol
Synonyms	10-Propargyl-5-methyl-5-deazaaminopterin; 5-Methyl-5-deaza-10-propargylaminopterin; NSC 781998; Propargyl-Deazaaminopterin Analog; Antifolate Research Compound; DHFR Inhibitor Analog; 2-[[4-[(2,4-Diamino-5-methyl-5,6,7,8-tetrahydro-6-pteridinyl)methyl]propargylamino]benzoyl]glutamic Acid
EINECS	Contact for details

Quality Control

Our 10-Propargyl-5-Methyl-5-Deazaaminopterin Analog is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.