Description

Ibuprofenyl-Coenzyme A CAS NO 135027-64-4 is a specialized biochemical conjugate, formed by linking the non-steroidal anti-inflammatory drug (NSAID) ibuprofen to coenzyme A (CoA). This compound is a critical intermediate in the study of drug metabolism and the biosynthesis of novel hybrid metabolites. It is primarily utilized by pharmaceutical researchers and biochemists engaged in advanced metabolic pathway analysis, enzyme mechanism studies, and the development of targeted prodrugs or anti-inflammatory agents.

Application

• Metabolic Pathway Research: A key substrate for investigating the enzymatic conjugation and metabolic fate of ibuprofen and related profens.
• Enzyme Activity Assays: Used as a cofactor or substrate in in vitro assays to study acyl-CoA synthetases and transferases.
• Bioconjugate & Prodrug Development: Serves as a precursor for synthesizing novel ibuprofen-containing bioconjugates with potential therapeutic applications.
• Biochemical Tool Compound: Employed in mechanistic studies to understand the role of CoA-thioesters in cellular signaling and inflammation.
• Academic & Pharmaceutical R&D: Essential for basic research and drug discovery programs focused on lipid metabolism and NSAID pharmacology.

Basic Information

Product Name	Ibuprofenyl-Coenzyme A
CAS No.	135027-64-4
Molecular Formula	C42H68N7O19P3S
Molecular Weight	~1124.0 g/mol
Synonyms	Ibuprofen-CoA; Ibuprofen Coenzyme A Thioester; (R,S)-2-(4-Isobutylphenyl)propionyl-CoA; Ibuprofenyl-CoA; CoA-Ibuprofen; Acyl-Coenzyme A Ibuprofen; Ibuprofen CoA Conjugate; 4-Isobutyl-α-methylphenylacetic Acid Coenzyme A Ester
EINECS	Contact for details

Quality Control

Our Ibuprofenyl-Coenzyme A is produced under controlled conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation via mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (UV Spectrophotometry)	≥ 90%
Water Content (Karl Fischer)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.