Description

Phosphomannose Isomerase-Guanosine Diphospho-D-Mannose Pyrophosphorylase is a high-purity, dual-enzyme system critical for biochemical research and diagnostic applications. This compound is essential for studying and manipulating nucleotide-sugar metabolic pathways, particularly those involving GDP-mannose. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in enzymology, glycobiology, and the development of novel therapeutic or diagnostic assays.

Application

• Biochemical Research: A key reagent for in vitro studies of mannose metabolism, nucleotide-sugar biosynthesis, and glycosylation pathways.
• Enzyme Assay Development: Used as a standard or component in developing high-throughput screening assays for enzyme activity and inhibitor discovery.
• Diagnostic Kit Manufacturing: Incorporated into specialized diagnostic kits for the detection of specific metabolic disorders related to carbohydrate metabolism.
• Glycobiology Studies: Essential for the enzymatic synthesis of GDP-mannose and related sugar nucleotides used in oligosaccharide and glycoconjugate synthesis.
• Pharmaceutical R&D: Supports research into antibiotics, antivirals, and other therapeutics that target bacterial or fungal cell wall biosynthesis.
• Academic Research: Used in university and institutional labs for teaching and advanced research in molecular biology and biochemistry.

Basic Information

Item	Detail
Product Name	Phosphomannose Isomerase-Guanosine Diphospho-D-Mannose Pyrophosphorylase
CAS No.	134688-81-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PMI-GDPMP; GDP-Mannose Pyrophosphorylase with Phosphomannose Isomerase; EC 5.3.1.8 / EC 2.7.7.13; Mannose-6-phosphate isomerase; Guanosine diphosphomannose pyrophosphorylase; Phosphomannomutase/phosphoglucomutase related enzyme system; Nucleotide-sugar biosynthesis enzyme complex
EINECS	Contact for details

Quality Control

Our Phosphomannose Isomerase-Guanosine Diphospho-D-Mannose Pyrophosphorylase is produced and tested under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high specific activity, purity, and stability. Certificates of Analysis (COA) detailing assay results, purity, and activity units are provided with every shipment to guarantee reproducibility and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and should be handled under controlled, dry conditions to maintain optimal enzymatic activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to structure
Protein Content (Biuret)	> 90%
Specific Activity	> 50 units/mg protein
Purity (SDS-PAGE)	> 95%
pH (in solution)	7.0 - 7.5
Endotoxin (LAL)	< 1.0 EU/mg
Solubility	Soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.