Description

4-Methylumbelliferyl-2-Deoxy-2-Acetamido-6-o-Sulfoglucosamine is a specialized fluorogenic substrate used for the detection and quantification of specific enzymatic activity. This compound matters for researchers and quality control labs requiring high-sensitivity, precise biochemical assays. It is primarily needed by the life science, pharmaceutical, and diagnostic industries for applications in enzyme kinetics, inhibitor screening, and diagnostic reagent development.

Application

• Fluorogenic substrate for the assay of N-acetylglucosamine-6-sulfatase (G6S) activity, a key enzyme in lysosomal storage disorder research (e.g., Sanfilippo syndrome type D).
• Critical reagent in enzymatic diagnostic kits for the detection of specific sulfatase deficiencies.
• Tool compound for high-throughput screening (HTS) campaigns to identify potential therapeutic enzyme inhibitors or activators.
• Used in biochemical research to study enzyme kinetics, specificity, and mechanism of action of sulfatases.
• Essential component in quality control (QC) testing for enzyme replacement therapies and related biopharmaceuticals.
• Applied in academic and institutional research focused on glycosaminoglycan (GAG) metabolism and related pathologies.

Basic Information

Product Name	4-Methylumbelliferyl-2-Deoxy-2-Acetamido-6-o-Sulfoglucosamine
CAS No.	134268-92-1
Molecular Formula	C₁₈H₂₀N₂O₁₂S
Molecular Weight	488.42 g/mol
Synonyms	4-MU-2-Deoxy-2-Acetamido-6-o-Sulfo-β-D-Glucopyranoside; 4-Methylumbelliferyl-6-Sulfo-2-Acetamido-2-Deoxy-β-D-Glucopyranoside; 4-MU-β-GlcNAc-6S; G6S Substrate; N-Acetylglucosamine-6-Sulfatase Substrate; 4-Methylumbelliferyl N-Acetyl-6-Sulfo-β-D-glucosaminide; Fluorogenic G6S Substrate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and diagnostic use. Each batch is characterized to confirm identity, purity, and functional performance as a specific enzyme substrate. Certificates of Analysis (COA) detailing purity (by HPLC), spectral data, and functional assay results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Functional Activity	Suitable for enzyme assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.