Description

D(+) Erythro-2-Amino-4-trans-Octadecene-1,3-Diol [3-3H] is a tritium-labeled, high-purity sphingoid base derivative, a critical building block in lipid biochemistry and pharmaceutical research. This compound is essential for metabolic pathway tracing, receptor binding studies, and the synthesis of radiolabeled sphingolipids, enabling precise, quantitative analysis in biological systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on lipidomics, cancer research, and neurological disease mechanisms.

Application

• Biochemical Tracer Studies: Used as a radiolabeled precursor for tracking the biosynthesis, metabolism, and intracellular transport of complex sphingolipids.
• Pharmaceutical R&D: Serves as a key intermediate in the synthesis of novel, labeled therapeutic agents targeting sphingolipid-mediated pathways in oncology and immunology.
• Enzyme Assay Substrate: Employed in high-throughput screening (HTS) and kinetic studies for enzymes like ceramide synthases and sphingosine kinases.
• Receptor Binding & Signal Transduction Research: Facilitates the study of sphingosine-1-phosphate (S1P) and other lipid mediator receptors.
• Diagnostic Kit Development: Incorporated into assay kits for the detection and quantification of specific sphingolipid metabolites in clinical samples.
• Academic Lipidomics Research: A vital tool for investigating the role of sphingolipids in cell membrane structure, apoptosis, and cellular stress responses.

Basic Information

Item	Detail
Product Name	D(+) Erythro-2-Amino-4-trans-Octadecene-1,3-Diol [3-3H]
CAS No.	134102-05-9
Molecular Formula	C18H37NO2 (³H)
Molecular Weight	~299.5 g/mol (unlabeled)
Synonyms	(2S,3R,4E)-2-Amino-4-Octadecene-1,3-diol [3-³H]; D-erythro-Sphingosine [3-³H]; (2S,3R,4E)-2-Amino-4-Octadecene-1,3-diol (tritium labeled); trans-D-erythro-2-Amino-4-Octadecene-1,3-diol [3-³H]; Radiolabeled Sphingosine; Tritiated Sphingoid Base; Sphing-4-enine [3-³H]; 4-trans-D-erythro-Sphingosine [3-³H]
EINECS	Contact for details

Quality Control

Every batch of our tritium-labeled D(+) Erythro-2-Amino-4-trans-Octadecene-1,3-Diol is manufactured and tested under stringent quality systems to ensure high specific activity, radiochemical purity, and chemical stability. Our quality commitment includes comprehensive analytical characterization via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying radionuclidic purity, specific activity (Ci/mmol), and solvent composition to meet the exacting standards of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C in the original solvent as specified on the label and COA. This product is light-sensitive (store away from light) and solutions should be handled under inert atmosphere to minimize decomposition. Always adhere to local regulations for the storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	10-30 Ci/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 90%
Solvent	Ethanol or custom solvent system
Concentration	1.0 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.