Description

Oxythiamine Disulfide is a synthetic, biologically active derivative of thiamine (vitamin B1) that functions as a potent and specific antagonist of thiamine-dependent enzymes. This compound is a critical research tool for studying thiamine metabolism and its role in cellular energy production and neurological function. It is primarily utilized by researchers in the fields of biochemistry, pharmacology, and nutrition science to investigate metabolic pathways and model thiamine deficiency states in vitro.

Application

• Biochemical Research: As a specific inhibitor of thiamine pyrophosphokinase (TPK) and transketolase, used to study thiamine-dependent enzymatic processes in metabolic pathways like the pentose phosphate pathway.
• Pharmacological Studies: Employed to induce experimental thiamine deficiency in cell cultures and animal models to investigate the physiological and neurological consequences.
• Nutritional Science Research: Used to explore the mechanisms of thiamine transport, metabolism, and the biochemical basis of conditions like beriberi and Wernicke-Korsakoff syndrome.
• Enzyme Mechanism Analysis: A key compound for probing the active sites and catalytic mechanisms of thiamine diphosphate (ThDP)-dependent enzymes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and research laboratories.

Basic Information

Product Name	Oxythiamine Disulfide
CAS No.	134028-70-9
Molecular Formula	C24H32N8O4S2
Molecular Weight	560.70 g/mol
Synonyms	Oxythiamine Disulfide; Oxy-thiamine Disulfide; Thiamine Antagonist; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride, Disulfide Form; Vitamin B1 Antagonist; Thiamine Pyrophosphokinase Inhibitor
EINECS	Contact for details

Quality Control

Our Oxythiamine Disulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.