Description

S-(1-Hydroxy-3-Buten-2-Yl)Glutathione is a specialized, biologically relevant glutathione derivative, a key conjugate in the study of metabolic pathways involving reactive intermediates. This compound is of significant value in biochemical and pharmaceutical research for investigating detoxification mechanisms and oxidative stress responses. It is primarily utilized by researchers and developers in the fields of pharmaceutical development, toxicology studies, and advanced biochemical research.

Application

• Biochemical Research: A critical reference standard and intermediate for studying glutathione S-transferase (GST) activity and conjugation reactions.
• Metabolite Identification: Used in the identification and quantification of mercapturic acid pathway metabolites in toxicological and pharmacokinetic studies.
• Pharmaceutical Development: Serves as a key biomarker and reference compound in the development of drugs targeting oxidative stress and detoxification pathways.
• Toxicology & Safety Assessment: Employed to investigate the metabolic fate of xenobiotics and their covalent binding to cellular nucleophiles.
• Analytical Standard: Essential for calibrating analytical methods such as LC-MS/MS and HPLC in bioanalytical laboratories.
• Enzyme Mechanism Studies: Utilized as a substrate or inhibitor analog to probe the catalytic mechanisms of enzymes involved in glutathione metabolism.

Basic Information

Product Name	S-(1-Hydroxy-3-Buten-2-Yl)Glutathione
CAS No.	133872-49-8
Molecular Formula	C14H24N3O8S
Molecular Weight	394.42 g/mol
Synonyms	S-(1-Hydroxybut-3-en-2-yl)glutathione; 1-Hydroxy-3-buten-2-yl Glutathione; Glutathione, S-(1-hydroxy-3-buten-2-yl)-; Butadiene monoxide-glutathione conjugate; 1,2-Epoxy-3-butene-glutathione adduct; BM-GSH Conjugate; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our S-(1-Hydroxy-3-Buten-2-Yl)Glutathione is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for research applications. All products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under dry, inert gas (e.g., nitrogen or argon) and allowed to equilibrate to room temperature in a desiccator before opening to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.