Description

n-(11-(1-Pyrene)Sulfonylaminoundecanoyl)Sphingomyelin is a specialized, fluorescently labeled derivative of sphingomyelin, a key phospholipid component of cell membranes. This compound is engineered for advanced research applications, where its pyrene fluorophore enables precise tracking and analysis of lipid dynamics and membrane processes. It is an essential tool for researchers and scientists in biochemistry, cell biology, and biophysics who require high-purity, well-characterized probes for fluorescence spectroscopy, microscopy, and membrane trafficking studies.

Application

• Fluorescence Spectroscopy Studies: Used as a probe to investigate lipid-lipid interactions, membrane fluidity, and phase transitions in model and cellular membranes.
• Cellular Imaging & Microscopy: Enables visualization and tracking of sphingomyelin metabolism, distribution, and trafficking within live or fixed cells.
• Lipid Raft & Membrane Domain Research: Serves as a critical tool for studying the organization and function of sphingolipid-enriched membrane microdomains.
• Enzyme Activity Assays: Acts as a substrate for studying the activity of sphingomyelinases and other enzymes involved in sphingomyelin catabolism.
• Liposome & Model Membrane Preparation: Incorporated into liposomes to create fluorescently labeled membrane models for biophysical and delivery studies.
• Drug Delivery & Targeting Research: Utilized in the development and analysis of lipid-based nanoparticle systems for targeted therapeutic delivery.

Basic Information

Product Name	n-(11-(1-Pyrene)Sulfonylaminoundecanoyl)Sphingomyelin
CAS No.	133733-41-2
Molecular Formula	C56H88N4O11PS
Molecular Weight	1055.35 g/mol
Synonyms	Pyrene-Sphingomyelin; N-((11-((1-Pyrenylsulfonyl)amino)undecanoyl))-sphingosylphosphorylcholine; 1-O-(N-(11-((1-Pyrenesulfonyl)amino)undecanoyl)sphingosyl)-2-O-acetyl-sn-glycero-3-phosphocholine (related analog); Fluorescent Sphingomyelin; Pyrene-labeled Sphingomyelin; SM(pyrene); N-(11-(1-Pyrenesulfonamido)undecanoyl)sphingosine-1-phosphocholine
EINECS	Contact for details

Quality Control

Every batch of our n-(11-(1-Pyrene)Sulfonylaminoundecanoyl)Sphingomyelin is produced and analyzed under strict quality protocols to ensure the highest standards of purity and batch-to-batch consistency, critical for sensitive research applications. Our quality assurance includes comprehensive analytical characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is easily oxidized; handling under an inert atmosphere (argon or nitrogen) is recommended for optimal preservation, especially when opening the primary container. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, DMSO; sparingly soluble in methanol
Fluorescence Properties	Excitation ~344 nm, Emission ~376 nm & 397 nm (monomer)
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.