Description

n-Acetyl-De-o-Sulfated Heparin Sodium Salt is a chemically modified derivative of heparin, designed for specific research and development applications. This compound is valued for its altered biological activity and reduced anticoagulant properties compared to native heparin, making it a crucial tool for studying structure-activity relationships. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors, particularly in the fields of glycobiology, drug discovery, and the development of novel therapeutic agents.

Application

• Biomedical Research: A key reagent for investigating heparin-protein interactions, enzymatic processes, and cellular signaling pathways without strong anticoagulant interference.
• Drug Discovery & Development: Used as a lead compound or intermediate in the R&D of new anti-inflammatory, anti-angiogenic, or antiviral therapeutics.
• Glycobiology Studies: Essential for exploring the structure-function relationship of glycosaminoglycans (GAGs) and their role in biological systems.
• Enzyme Inhibition Studies: Serves as a substrate analog or inhibitor in assays to study the activity of sulfatases, heparanase, and other GAG-modifying enzymes.
• Cell Culture & Tissue Engineering: Potential application as a component in specialized growth media or scaffolds to modulate cell growth and differentiation.
• Diagnostic Reagent Development: Can be used in the development of diagnostic kits and assays that require specific heparin derivatives.

Basic Information

Product Name	n-Acetyl-De-o-Sulfated Heparin Sodium Salt
CAS No.	133686-69-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetyl-desulfated Heparin Sodium Salt; De-O-Sulfated, N-Acetylated Heparin Sodium Salt; N-Acetyl Heparin (De-O-Sulfated); Partially Desulfated N-Acetyl Heparin; Heparin Derivative, N-Acetyl-De-O-Sulfated; Modified Heparin Sodium Salt; Glycosaminoglycan Derivative
EINECS	Contact for details

Quality Control

Our n-Acetyl-De-o-Sulfated Heparin Sodium Salt is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which includes data from methods such as NMR, HPLC, and functional assays. Specifications are aligned with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. Avoid exposure to excessive heat and humidity.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC / Titration)	≥ 95% (or as per grade)
Degree of N-Acetylation	Contact for details
Degree of De-O-Sulfation	Contact for details
Anticoagulant Activity (APTT)	Significantly reduced vs. native heparin
Water Content (KF)	≤ 5.0%
Residue on Ignition (Sulfated Ash)	Contact for details
Endotoxin (LAL)	< 1.0 EU/mg (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.