Description

D-Alanine-3-13C CAS NO 133665-48-2 is a stable isotope-labeled analog of the non-essential amino acid D-alanine, specifically enriched with carbon-13 at the 3-position. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing and quantification in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, metabolic flux analysis, and the development of diagnostic agents.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism and quantify intracellular reaction rates in microbial, plant, and mammalian systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in mass spectrometry for the accurate quantification of D-alanine and related metabolites in biological fluids.
• Biomolecular NMR Spectroscopy: Provides site-specific isotopic labeling to simplify complex NMR spectra for protein structure and dynamics studies.
• Proteomics and Peptide Research: Incorporated into synthetic peptides and proteins for mass spectrometry-based detection and quantification.
• Microbial Physiology Studies: Employed to investigate bacterial cell wall biosynthesis, particularly in studies of antibiotic resistance involving D-alanine metabolism.
• Diagnostic Agent Development: A potential precursor in the synthesis of labeled compounds for positron emission tomography (PET) or other imaging modalities.

Basic Information

Item	Detail
Product Name	D-Alanine-3-13C
CAS No.	133665-48-2
Molecular Formula	C213CH7NO2
Molecular Weight	90.09 g/mol (for 13C1 labeled)
Synonyms	(R)-2-Amino(3-13C)propanoic Acid; D-2-Aminopropionic Acid-3-13C; (R)-Alanine-3-13C; D-α-Alanine-3-13C; (R)-(-)-Alanine-3-13C; D-Ala-3-13C; (2R)-2-Azaniumyl(3-13C)propanoate
EINECS	Contact for details

Quality Control

Our D-Alanine-3-13C is produced under strict quality management protocols to ensure exceptional isotopic and chemical purity, essential for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, chiral purity, and results from specific identity tests. We support compliance with relevant research and development standards, and custom specifications can be developed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.