Description

Dioctadecylamidospermine CAS NO 133294-12-9 is a high-purity, synthetic cationic lipid derivative. This compound is valued for its unique ability to facilitate the delivery of genetic material into cells, making it a critical component in advanced research and therapeutic development. It is primarily sought by researchers and manufacturers in the biotechnology and pharmaceutical industries working on gene therapy, vaccine development, and nucleic acid delivery systems.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural and functional component in the creation of LNPs for the encapsulation and delivery of mRNA, siRNA, and other nucleic acids.
• Gene Therapy Research: Used as a transfection reagent in non-viral vector systems to introduce therapeutic genes into target cells in vitro and in vivo.
• Vaccine Development: Employed in the formulation of novel vaccine platforms, particularly for mRNA-based vaccines, to enhance cellular uptake and immunogenicity.
• Drug Delivery Systems: Serves as a cationic lipid in the design of targeted delivery systems for various therapeutic agents beyond nucleic acids.
• Biochemical Research: A tool compound for studying membrane interactions, cellular uptake mechanisms, and the structure-activity relationships of cationic lipids.
• Cosmetic & Dermatological Actives Delivery: Potential use in advanced cosmetic formulations for the enhanced skin delivery of active ingredients.

Basic Information

Item	Details
Product Name	Dioctadecylamidospermine
CAS No.	133294-12-9
Molecular Formula	C₄₂H₈₉N₅O
Molecular Weight	688.2 g/mol
Synonyms	N1,N14-Bis(octadecyl)-3,12-diaza-6,9-dioxa-2,13-diazatetradecanediamide; DOSPA; 2,3-Dioleyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate (common trade name component); Cationic lipid 2,3-dioleyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium; Lipofectamine component analog; Spermine-based cationic lipid; N,N-Dioctadecylspermine-5-carboxamide; Transfection lipid
EINECS	Contact for details

Quality Control

Our Dioctadecylamidospermine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Allow the sealed container to reach room temperature before opening to minimize condensation and hygroscopic uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.