Description

6-Mannopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate is a specialized nucleoside derivative, a key building block in the synthesis of modified oligonucleotides and nucleotide analogs. This compound is critical for researchers and manufacturers developing novel therapeutic agents, diagnostic probes, and tools for molecular biology. It is primarily utilized in pharmaceutical R&D, particularly in the fields of antisense technology, prodrug development, and the creation of nucleotide-based active pharmaceutical ingredients (APIs).

Application

• Antisense Oligonucleotide Synthesis: Serves as a modified phosphoramidite monomer for introducing specific functional groups into oligonucleotide chains.
• Prodrug Development: Used in the design and synthesis of nucleotide prodrugs for enhanced cellular delivery and therapeutic efficacy.
• Pharmaceutical Research: A crucial intermediate in the development of novel antiviral and anticancer nucleotide analogs.
• Bioconjugation & Labeling: The azido group enables click chemistry reactions for site-specific labeling and conjugation with biomolecules.
• Glycobiology Studies: Used as a tool compound to study glycosylated nucleotide pathways and interactions.
• Diagnostic Probe Manufacturing: Incorporated into probes for detecting specific DNA/RNA sequences in diagnostic assays.

Basic Information

Product Name	6-Mannopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate
CAS No.	133163-37-8
Molecular Formula	C16H22N5O12P
Molecular Weight	507.35 g/mol
Synonyms	3'-Azido-3'-deoxy-5'-thymidinyl 6-mannopyranosyl phosphate; 6-O-(Thymidin-5'-ylphosphoryl)-D-mannopyranose 3'-azido-3'-deoxy derivative; AZT Mannosyl Phosphate; 3'-N3-Thd-5'-P-6-Man; 5'-(D-Mannopyranos-6-yl phosphate)-3'-azido-3'-deoxythymidine; Nucleoside Sugar Phosphate Conjugate
EINECS	Contact for details

Quality Control

Our 6-Mannopyranosyl 3'-Azido-3'-Deoxy-5'-Thymidinyl Phosphate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.