Description

(S)-1-Tosylpyrrolidin-3-Yl 4-Methylbenzenesulfonate CAS NO 133034-01-2 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in asymmetric synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex, stereochemically defined molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting neurological and metabolic disorders.
• Asymmetric Catalysis Ligand Precursor: Used to develop and synthesize novel chiral ligands for asymmetric hydrogenation and cross-coupling reactions.
• Protease Inhibitor Research: Serves as a core structural component in the research and development of protease enzyme inhibitors.
• Agrochemical Active Ingredient Synthesis: Employed in the creation of advanced, stereoselective agrochemicals with improved efficacy and environmental profiles.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory chemistry and method development.
• Peptidomimetic Scaffold Development: Utilized to construct constrained, non-natural amino acid analogs and peptidomimetic scaffolds for drug discovery.

Basic Information

Product Name	(S)-1-Tosylpyrrolidin-3-Yl 4-Methylbenzenesulfonate
CAS No.	133034-01-2
Molecular Formula	C18H21NO5S2
Molecular Weight	395.49 g/mol
Synonyms	(S)-1-Tosyl-3-pyrrolidyl Tosylate; (S)-3-[(4-Methylphenyl)sulfonyl]oxy-1-[(4-methylphenyl)sulfonyl]pyrrolidine; (S)-1-Tosylpyrrolidin-3-ol 4-Methylbenzenesulfonate; (S)-1-(p-Toluenesulfonyl)pyrrolidin-3-yl p-toluenesulfonate; (S)-3-(Tosyloxy)-1-(p-toluenesulfonyl)pyrrolidine; (S)-1-Tosyl-3-(tosyloxy)pyrrolidine; (S)-Pyrrolidine, 1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyl]oxy-
EINECS	Contact for details

Quality Control

Our (S)-1-Tosylpyrrolidin-3-Yl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.