Description

Ramosetron Hydrochloride CAS NO 132907-72-3 is a highly selective serotonin 5-HT₃ receptor antagonist used to prevent nausea and vomiting. It is valued for its potent and long-lasting antiemetic efficacy, particularly in clinical settings involving chemotherapy and post-operative recovery. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing injectable and oral formulations targeting chemotherapy-induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV).

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic drug formulations.
• Chemotherapy-Induced Nausea and Vomiting (CINV): Formulated into injectable solutions for prevention of acute and delayed nausea associated with highly emetogenic chemotherapy.
• Post-Operative Nausea and Vomiting (PONV): Used in pre-operative or post-operative medications to manage nausea following surgical procedures.
• Oral Solid Dosage Forms: Incorporated into tablets or capsules for convenient oral administration in specific treatment regimens.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research and new drug development projects.
• Generic Drug Manufacturing: Critical for companies producing generic versions of established 5-HT₃ antagonist antiemetics.

Basic Information

Product Name	Ramosetron Hydrochloride
CAS No.	132907-72-3
Molecular Formula	C₁₇H₂₁N₃O•HCl
Molecular Weight	319.83 g/mol
Synonyms	(R)-5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole Hydrochloride; Ramosetron HCl; Y-25130 Hydrochloride; Nasea® (Brand Name); Ramosetronum; UNII-3W6Q7QZ8VU
EINECS	Contact for details

Quality Control

Our Ramosetron Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.