Description

5-(((2,2,6,6-Tetramethyl-1-Oxy-4-Piperidyl)Amino)Methyl)-2'-Deoxyuridine is a specialized nitroxide-labeled nucleoside derivative, designed for advanced research and development. This compound is critical for applications requiring site-specific spin labeling, offering a stable free radical for precise structural and dynamic studies. It is primarily utilized by researchers and developers in the fields of biophysics, structural biology, and medicinal chemistry for probing nucleic acid structure, function, and interactions.

Application

• Site-Directed Spin Labeling (SDSL) of DNA and RNA for Electron Paramagnetic Resonance (EPR) spectroscopy studies.
• Probe for investigating nucleic acid structure, dynamics, and conformational changes in solution.
• Tool for studying protein-nucleic acid interactions and complex formation mechanisms.
• Research into distance measurements via pulsed EPR techniques like DEER (Double Electron-Electron Resonance).
• Development of novel diagnostic assays and sensors based on paramagnetic nucleotide analogs.
• Use as a building block in the synthesis of advanced biomaterials and molecular probes for biophysical research.

Basic Information

Product Name	5-(((2,2,6,6-Tetramethyl-1-Oxy-4-Piperidyl)Amino)Methyl)-2'-Deoxyuridine
CAS No.	132723-75-2
Molecular Formula	C19H32N4O6
Molecular Weight	412.48 g/mol
Synonyms	5-(TEMPO-Aminomethyl)-2'-deoxyuridine; 5-((4-Amino-2,2,6,6-tetramethylpiperidin-1-oxyl)methyl)-2'-deoxyuridine; Nitroxide-labeled deoxyuridine; TEMPO-dU; Spin-labeled dU; 5-((4-Amino-TEMPO)methyl)-2'-deoxyuridine; 5-(Aminomethyl-TEMPO)-2'-deoxyuridine; dU-TEMPO
EINECS	Contact for details

Quality Control

Our 5-(((2,2,6,6-Tetramethyl-1-Oxy-4-Piperidyl)Amino)Methyl)-2'-Deoxyuridine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant GMP and ISO guidelines for laboratory chemical manufacturing to guarantee reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.