Description

2',3'-Dideoxyadenosine-5'-o-Triphosphate Sodium Salt is a chemically modified nucleotide triphosphate analog where the ribose sugar lacks hydroxyl groups at both the 2' and 3' positions. This molecular structure is critical for its primary function as a chain terminator in enzymatic DNA synthesis, making it an indispensable tool in molecular biology research and diagnostics. It is essential for scientists and manufacturers engaged in advanced nucleic acid analysis, sequencing, and the development of antiviral therapeutics. The product is supplied as a high-purity sodium salt to ensure stability and consistent performance in sensitive biochemical applications.

Application

• DNA Sequencing & Analysis: Used as a chain-terminating substrate in Sanger sequencing and next-generation sequencing (NGS) platforms.
• Antiviral Research: Serves as a key intermediate or active metabolite in the study and development of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other viral infections.
• Enzymatic Synthesis: Employed in polymerase-based in vitro synthesis where incorporation of a 2',3'-dideoxy nucleotide is required to halt chain elongation.
• Molecular Diagnostics: Utilized in probe-based assays and PCR techniques for the detection of specific genetic markers or pathogens.
• Biochemical Research: Acts as a substrate for studying polymerase kinetics, fidelity, and mechanism of action.
• Pharmaceutical Development: Used as a reference standard or raw material in the quality control and manufacturing of antiviral active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2',3'-Dideoxyadenosine-5'-o-Triphosphate Sodium Salt
CAS No.	132619-65-9
Molecular Formula	C10H13N5O12P3Nax (x≈3)
Molecular Weight	~551.1 g/mol (Free acid, anhydrous basis)
Synonyms	2',3'-Dideoxyadenosine-5'-triphosphate sodium salt; ddATP-Na; 2',3'-ddATP Sodium Salt; Dideoxyadenosine triphosphate sodium; Adenosine, 2',3'-dideoxy-, 5'-(tetrahydrogen triphosphate), sodium salt; 2',3'-Dideoxy-ATP sodium; Cordycepin triphosphate sodium salt analog
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyadenosine-5'-o-Triphosphate Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and endotoxins where applicable. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. The product is suitable for research and development use under ISO 9001 guidelines, and custom synthesis to meet specific pharmacopeial (e.g., USP) standards is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep under inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area Percent)
Assay (UV)	90 - 110% of stated content
Water Content (KF)	≤ 5.0 %
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.