Description

n-ε-p-Tosyl-L-Lysine Ethyl Ester Hydrochloride is a protected derivative of the essential amino acid L-lysine, widely used as a key synthetic intermediate in peptide chemistry. Its primary value lies in providing a selectively protected ε-amino group, enabling the controlled synthesis of complex peptides and peptide mimetics. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis: A crucial building block in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of lysine residues.
• Pharmaceutical Research: Intermediate in the development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation: Used to introduce functional handles or linkers onto peptides for conjugation with other molecules, such as dyes, polymers, or drug payloads.
• Biochemical Tool Development: Serves as a precursor for synthesizing labeled peptides, affinity probes, and substrates for enzymatic studies.
• Academic & Industrial R&D: Fundamental reagent in research laboratories for exploring protein-protein interactions and structure-activity relationships (SAR).

Basic Information

Product Name	n-ε-p-Tosyl-L-Lysine Ethyl Ester Hydrochloride
CAS No.	132567-23-8
Molecular Formula	C16H26N2O4S • HCl
Molecular Weight	378.92 g/mol
Synonyms	Nε-Tosyl-L-lysine Ethyl Ester Hydrochloride; Nε-Tosyl-L-lysine O-Ethyl Ester Hydrochloride; L-Lysine, N6-(4-methylbenzenesulfonyl)-, ethyl ester, hydrochloride; Nα-Boc-Nε-Tosyl-L-lysine Ethyl Ester Hydrochloride (common starting material variant); H-Lys(Tos)-OEt • HCl; TLys-OEt • HCl; Tos-Lys-OEt • HCl
EINECS	Contact for details

Quality Control

Our n-ε-p-Tosyl-L-Lysine Ethyl Ester Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+15.0° to +18.0° (c=1 in Methanol)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.