Description

Crambescin B CAS NO 132210-63-0 is a bioactive guanidine alkaloid compound derived from marine sponge sources. This compound is of significant interest for its potent biological activity, particularly as a selective inhibitor of voltage-gated sodium channels. It serves as a valuable high-purity reference standard and research chemical for pharmaceutical discovery, neuroscience research, and the development of novel therapeutic agents targeting ion channel function.

Application

• Pharmaceutical Research & Development: As a key reference standard in drug discovery programs focused on ion channel modulators.
• Neuroscience Studies: For investigating the role and mechanism of voltage-gated sodium channels in cellular physiology and disease models.
• Biochemical Assays: Used as a selective tool compound in high-throughput screening (HTS) and in vitro pharmacological profiling.
• Academic Research: A critical reagent for universities and research institutes studying marine natural products and neuroactive substances.
• Analytical Standard: For the qualitative and quantitative analysis (e.g., via HPLC, LC-MS) of Crambescin B in complex matrices.

Basic Information

Product Name	Crambescin B
CAS No.	132210-63-0
Molecular Formula	C₂₀H₄₀N₈O₄
Molecular Weight	456.59 g/mol
Synonyms	Crambescin B; Crambescine B; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(4S)-4-Amino-4-carboxybutyl]amino]-4-guanidinobutanoyl]amino]-4-guanidinobutanoyl]amino]-4-guanidinobutanoyl]amino]-5-guanidinopentanoic Acid; Marine Sponge Alkaloid; Sodium Channel Inhibitor B
EINECS	Contact for details

Quality Control

Our Crambescin B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.