Description

9-[(2R,5S)-5-(Hydroxymethyl)Oxolan-2-Yl]-3H-Purine-2,6-Dione is a high-purity nucleoside derivative with significant pharmaceutical relevance. This compound serves as a critical building block in the synthesis of novel antiviral and anticancer agents, offering precise stereochemistry essential for biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside-based therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of antiviral drugs, particularly nucleoside reverse transcriptase inhibitors.
• Anticancer Agent Research: Used as a precursor in the development of purine nucleoside analogs targeting various cancer pathways.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for nucleoside-metabolizing enzymes.
• Diagnostic Probe Synthesis: Utilized in creating labeled nucleosides for molecular diagnostics and imaging techniques.
• Process Chemistry & Scale-Up: Serves as a starting material for process development and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	9-[(2R,5S)-5-(Hydroxymethyl)Oxolan-2-Yl]-3H-Purine-2,6-Dione
CAS No.	132194-28-6
Molecular Formula	C10H12N4O4
Molecular Weight	252.23 g/mol
Synonyms	(2R,5S)-5-(Hydroxymethyl)-2-(2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)tetrahydrofuran; 9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-3H-purine-2,6-dione; Dioxolane-T Purine Derivative; Nucleoside Analog Intermediate; (2'R,5'S)-Dioxolane Purine Nucleoside
EINECS	Contact for details

Quality Control

Our 9-[(2R,5S)-5-(Hydroxymethyl)Oxolan-2-Yl]-3H-Purine-2,6-Dione is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,5S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.