Description

(n-Succinimidyl 4-Pentynoate)Hexacarbonyldicobalt CAS NO 132178-38-2 is a specialized organometallic reagent that serves as a versatile click chemistry linker, combining a terminal alkyne group with an amine-reactive N-hydroxysuccinimide (NHS) ester. This compound is critical for researchers and manufacturers requiring precise, bioorthogonal conjugation strategies to label biomolecules, polymers, and surfaces. It is primarily utilized in the development of pharmaceuticals, advanced materials, and diagnostic tools within the biotechnology, life sciences, and materials science sectors.

Application

• Bioconjugation and Protein Labeling: Used to introduce terminal alkyne handles onto proteins, antibodies, and peptides via NHS-ester chemistry for subsequent click reactions with azides.
• Proteomics and Biomarker Discovery: Enables the tagging and enrichment of biomolecules for mass spectrometry analysis and activity-based protein profiling (ABPP).
• Polymer and Materials Functionalization: Acts as a crosslinker to modify surfaces, nanoparticles, and hydrogels with bio-orthogonal functional groups for creating smart materials.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies, a key step in targeted cancer therapy development.
• Diagnostic Assay Development: Employed in the synthesis of probes and reagents for fluorescence-based detection, ELISA, and other diagnostic platforms.
• Chemical Biology Tool Development: Serves as a fundamental building block for creating novel chemical probes to study biological pathways and enzyme functions.

Basic Information

Item	Details
Product Name	(n-Succinimidyl 4-Pentynoate)Hexacarbonyldicobalt
CAS No.	132178-38-2
Molecular Formula	C15H9Co2NO9
Molecular Weight	489.06 g/mol
Synonyms	4-Pentynoic Acid N-Succinimidyl Ester Hexacarbonyldicobalt Complex; NHS-Pentynyl-Cobalt Carbonyl; Cobalt Hexacarbonyl Alkyne NHS Ester; 4-Pentynoic Acid, 2,5-Dioxo-1-pyrrolidinyl Ester, Hexacarbonyldicobalt(Co-Co); Alkyne-Cobalt Carbonyl NHS Ester; Click Chemistry Cobalt Reagent; Dicobalt Hexacarbonyl Alkyne NHS Ester; N-Succinimidyl 4-Pentynoate Dicobalt Hexacarbonyl Complex
EINECS	Contact for details

Quality Control

Our (n-Succinimidyl 4-Pentynoate)Hexacarbonyldicobalt is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and FT-IR spectroscopy, to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Dark red to brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.