Description

9-Deaza-9-(3-Thienylmethyl)Guanine is a synthetic purine nucleoside analog, specifically engineered as a potent antiviral and potential anticancer research compound. Its core value lies in its mechanism of action as a nucleoside analog, which allows it to interfere with viral DNA replication and cellular proliferation processes. This makes it a critical intermediate and reference standard for pharmaceutical R&D, particularly in the development of novel antiviral therapies targeting herpesviruses and other DNA viruses. Researchers and manufacturers in the pharmaceutical and biotechnology sectors require this high-purity building block for drug discovery, biochemical studies, and process development.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel antiviral and anticancer drug candidates.
• Biochemical Research: Used as a reference standard and active compound in studies targeting viral polymerase inhibition and nucleoside metabolism.
• Antiviral Agent Development: A critical scaffold for researching treatments against herpes simplex virus (HSV), cytomegalovirus (CMV), and other DNA viruses.
• Oncology Research: Investigated for its potential antiproliferative effects in various cancer cell line studies.
• Enzyme Inhibition Studies: Employed to study the activity and kinetics of enzymes like guanine phosphoribosyltransferase.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and manufacturing processes for nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	9-Deaza-9-(3-Thienylmethyl)Guanine
CAS No.	132138-76-2
Molecular Formula	C11H11N5OS
Molecular Weight	261.30 g/mol
Synonyms	9-[(3-Thienylmethyl)-9-deaza]guanine; 9-Deaza-9-(3-thienylmethyl)guanine; 9H-Purin-6-amine, 9-[(3-thienylmethyl)-9-deaza]-; 9-(3-Thienylmethyl)-9-deazaguanine; 3-Thienylmethyl-9-deazaguanine; NSC 694501; Acyclonucleoside analog
EINECS	Contact for details

Quality Control

Our 9-Deaza-9-(3-Thienylmethyl)Guanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.