Description

n-Diazirinyl-Lyso-G(M1) CAS NO 131966-72-8 is a specialized, high-purity biochemical reagent featuring a diazirine photoaffinity label. This compound is critical for advanced proteomics and lipidomics research, enabling the covalent cross-linking and identification of protein-lipid interactions under controlled photolysis. It is primarily utilized by research scientists and process developers in pharmaceutical R&D, academic biochemistry, and diagnostic kit manufacturing for studying membrane proteins and glycolipid biology.

Application

• Photoaffinity Labeling: As a key reagent for cross-linking and capturing transient interactions between proteins and glycosphingolipids like GM1.
• Membrane Protein Research: For the structural and functional analysis of ganglioside-binding proteins and receptors in lipid raft studies.
• Proteomics Workflows: Integration into mass spectrometry-based platforms for identifying and characterizing novel lipid-binding protein targets.
• Drug Discovery: Used in target identification and validation stages for diseases involving glycolipid metabolism, such as certain lysosomal storage disorders.
• Bioconjugation & Probe Development: Serves as a precursor for synthesizing more complex activity-based probes (ABPs) for enzymatic studies.
• Diagnostic Assay Development: Potential use in developing high-sensitivity assays for antibodies or ligands targeting specific glycosphingolipid epitopes.

Basic Information

Product Name	n-Diazirinyl-Lyso-G(M1)
CAS No.	131966-72-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lyso-GM1 Diazirine; 3-(Trifluoromethyl)-3-phenyldiazirine-Lyso-GM1; Photoaffinity Lyso-GM1; GM1 Ganglioside Photoaffinity Probe; Diazirine-modified Lyso-GM1; n-Diazirinyl Lyso-Ganglioside GM1; Lyso-G(M1) Diazirine Derivative
EINECS	Contact for details

Quality Control

Every batch of n-Diazirinyl-Lyso-G(M1) is produced and analyzed under strict quality management protocols to ensure high purity and batch-to-batch consistency, essential for reproducible research outcomes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and strictly light-sensitive nature, the material should be handled in a controlled, moisture-free environment and allowed to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.