Description

1-o-Hexadecyl-2-(Homo-Gamma Linolenoyl)-Sn-Glycero-3-Phosphocholine is a synthetic, high-purity phospholipid analog, specifically an ether-linked phosphatidylcholine derivative. This compound is of significant value as a critical biochemical tool and a potential precursor in advanced lipid-based drug delivery systems. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in membrane biophysics, liposome formulation, and targeted therapeutic development.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: Serves as a key structural and functional lipid component for creating stable vesicles for drug and nucleic acid (e.g., mRNA) delivery.
• Membrane Biophysics Research: Used as a model membrane lipid to study lipid raft formation, membrane fluidity, and protein-lipid interactions due to its defined ether-linked alkyl chain.
• Biochemical Probe Development: Acts as a substrate or inhibitor in enzymatic assays targeting phospholipases (e.g., PLA2) or other lipid-modifying enzymes.
• Cell Signaling Studies: Investigated for its role as a potential precursor or analog in eicosanoid and lipid mediator signaling pathways.
• Pharmaceutical Intermediate: Utilized in the synthesis of more complex, targeted phospholipid conjugates for advanced therapeutic applications.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in lipidomics and related fields.

Basic Information

Product Name	1-o-Hexadecyl-2-(Homo-Gamma Linolenoyl)-Sn-Glycero-3-Phosphocholine
CAS No.	131907-73-8
Molecular Formula	C₄₂H₈₀NO₈P
Molecular Weight	758.06 g/mol
Synonyms	1-O-Hexadecyl-2-(homo-γ-linolenoyl)-sn-glycero-3-phosphocholine; C16:0-e-GLPC; Ether-Linked Homo-γ-Linolenoyl Phosphatidylcholine; 1-O-Hexadecyl-2-(8,11,14-eicosatrienoyl)-sn-glycero-3-phosphocholine; HGLC; Platelet-Activating Factor (PAF) Analog; Synthetic Phospholipid; sn-Glycero-3-phosphocholine, 1-O-hexadecyl-2-(homo-γ-linolenoyl)-
EINECS	Contact for details

Quality Control

Our 1-o-Hexadecyl-2-(Homo-Gamma Linolenoyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity (by HPLC/NMR), identity confirmation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98% of theoretical
Solvent Content (Residual Solvents)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.