Description

n-Acetyl-D3-S-(n-Methylcarbamoyl)-L-Cysteine is a deuterated derivative of a key mercapturic acid metabolite, specifically designed for advanced analytical applications. This compound is essential for researchers and quality control laboratories requiring high-purity, isotopically labeled internal standards for precise quantification. It is primarily utilized in the pharmaceutical, agrochemical, and environmental testing sectors for method development and validation in mass spectrometry. Its stable isotope labeling ensures accurate and reliable data in complex biological and chemical matrices.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of parent compounds or their metabolites in pharmacokinetic and toxicokinetic studies.
• Biomarker Research: Used in the development and validation of analytical methods for detecting specific mercapturic acid adducts as biomarkers of exposure to industrial chemicals or pesticides.
• Drug Metabolism Studies: Facilitates the detailed investigation of metabolic pathways, particularly those involving glutathione conjugation (Phase II metabolism).
• Environmental and Food Safety Analysis: Enables precise monitoring of chemical residues and their human metabolites in environmental samples and food products.
• Reference Material: Acts as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring regulatory compliance in GLP/GMP environments.
• Proteomics and Biochemical Research: Can be employed in studies investigating the role of specific cysteine adducts in protein function and cellular signaling pathways.

Basic Information

Product Name	n-Acetyl-D3-S-(n-Methylcarbamoyl)-L-Cysteine
CAS No.	131685-10-4
Molecular Formula	C7H9D3N2O4S
Molecular Weight	221.25 g/mol
Synonyms	N-Acetyl-S-(N-methylcarbamoyl)-D3-L-cysteine; N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine-d3; N-Acetyl-S-(methylcarbamoyl)-L-cysteine-d3; Mercapturic Acid Metabolite-d3 (of N-methylcarbamate); L-Cysteine, N-acetyl-3-[(methylamino)carbonyl]thio]-, methyl-d3-; d3-NAC-MC; Deuterated N-Acetyl-S-(N-methylcarbamoyl)cysteine
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-D3-S-(n-Methylcarbamoyl)-L-Cysteine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for use as an internal standard in regulated bioanalysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium, D)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.