Description

n-Biotinyl-3-Aminopropyl Solketal CAS NO 131606-43-4 is a specialized biotin derivative where the biotin moiety is linked to a solketal-protected aminopropyl spacer. This compound is engineered to provide a protected, reactive handle for bioconjugation, offering enhanced stability and solubility in organic synthesis compared to free biotin reagents. It is a critical intermediate for researchers and manufacturers developing biotinylated probes, affinity ligands, and targeted drug delivery systems in the pharmaceutical and life science sectors.

Application

• Synthesis of Biotinylated Probes: A key building block for creating biotin-labeled molecules used in diagnostic assays, histochemistry, and blotting techniques (e.g., ELISA, Western Blot).
• Affinity Chromatography Ligand Preparation: Used to functionalize solid supports (e.g., agarose beads) for the purification of proteins and other biomolecules via streptavidin-biotin interaction.
• Drug Conjugate Development: Serves as a linker-payload component in the design of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Surface Functionalization: Employed to introduce biotin groups onto nanoparticles, biosensors, and microarray surfaces for capture and detection applications.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions, cellular trafficking, and other biological processes using biotin-streptavidin technology.
• Protecting Group Strategy: The solketal group provides a protected diol, which can be deprotected under mild acidic conditions to reveal hydroxyl groups for further chemical modification.

Basic Information

Product Name	n-Biotinyl-3-Aminopropyl Solketal
CAS No.	131606-43-4
Molecular Formula	C21H37N3O5S
Molecular Weight	443.60 g/mol
Synonyms	Biotin-aminopropyl solketal; 1,2-O-Isopropylidene-3-O-(3-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)amino)propyl)-sn-glycerol; 3-O-[3-(Biotinylamino)propyl]-1,2-O-isopropylidene-sn-glycerol; Biotin-PEG-solketal; Biotinylated solketal derivative; N-Biotinyl-3-aminopropyl-1,2-O-isopropylidene-sn-glycerol; Biotin-AP-solketal
EINECS	Contact for details

Quality Control

Our n-Biotinyl-3-Aminopropyl Solketal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.