Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-Tris is a high-purity synthetic phospholipid derivative, a critical component in advanced drug delivery and formulation research. Its unique structure provides a versatile foundation for creating stable, biocompatible lipid-based systems. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing next-generation therapeutics, including liposomal drug carriers, mRNA vaccines, and diagnostic agents.

Application

• Lipid Nanoparticle (LNP) Formulation: A key excipient for encapsulating and delivering sensitive bioactive molecules, such as mRNA and siRNA, in therapeutic applications.
• Liposome Production: Used as a structural phospholipid to create stable, uniform liposomes for targeted drug delivery and diagnostic imaging.
• Biomimetic Membrane Research: Serves as a model membrane component for studying cell membrane dynamics, protein-lipid interactions, and membrane fusion processes.
• Pharmaceutical Excipient: Employed in the development of solubilizing agents and emulsion-based formulations to enhance the bioavailability of poorly soluble drugs.
• Cosmetic & Dermal Delivery Systems: Incorporated into advanced cosmetic formulations like niosomes and transfersomes for improved skin penetration and active ingredient stability.
• Diagnostic Reagent Development: Utilized in the preparation of reagents for clinical diagnostics and biochemical assays requiring specific membrane environments.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-Tris
CAS No.	131235-28-4
Molecular Formula	C45H85O13P
Molecular Weight	865.13 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate); PI(3,4,5)P3 (18:1); DOPI(3,4,5)P3; Phosphatidylinositol (3,4,5)-trisphosphate (Dioleoyl); 1,2-Dioleoylphosphatidylinositol 3,4,5-trisphosphate; Inositol 1,3,4,5-tetrakisphosphate 1-(1,2-dioleoyl-sn-glycero-3-phosphate); DOPtdIns(3,4,5)P3
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho-Tris is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.