Description

Buthionine Sulfoximine Ethyl Ester is a potent and selective inhibitor of γ-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis. This compound is a critical research tool for depleting intracellular glutathione levels, enabling the study of oxidative stress, drug resistance, and cellular detoxification pathways. It is essential for researchers and developers in the fields of oncology, neurobiology, and toxicology, where modulating redox balance is key to understanding disease mechanisms and therapeutic interventions.

Application

• Biomedical Research: A fundamental reagent for studying the role of glutathione in cancer cell apoptosis, chemoresistance, and radiation sensitivity.
• Pharmacology & Toxicology: Used to investigate oxidative stress-induced cell damage, neurotoxicity, and hepatotoxicity in experimental models.
• Drug Discovery: Employed in screening assays to identify compounds that are more effective under conditions of glutathione depletion.
• Biochemical Studies: Serves as a key inhibitor in enzymatic assays to study the γ-glutamyl cycle and amino acid transport.
• Academic & Institutional Research: Widely used in university and government laboratories for basic science research into cellular redox regulation.

Basic Information

Product Name	Buthionine Sulfoximine Ethyl Ester
CAS No.	131202-22-7
Molecular Formula	C9H18N2O4S
Molecular Weight	250.31 g/mol
Synonyms	BSO Ethyl Ester; L-Buthionine-(S,R)-sulfoximine Ethyl Ester; Buthionine Sulfoximine Ethyl Ester Hydrochloride (common salt form); Ethyl (2S)-2-Amino-4-{[(1R)-1-carboxy-3-[(carboxymethyl)amino]-3-oxopropyl]sulfonimidoyl}butanoate; γ-Glutamylcysteine Synthetase Inhibitor; GCS Inhibitor; Glutathione Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Buthionine Sulfoximine Ethyl Ester is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reproducible and reliable experimental results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.