Description

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanyl α-D-Glucuronide is a specific glucuronide metabolite of a nitrosamine, primarily used as a critical reference standard in analytical and toxicological research. Its precise chemical structure makes it an essential tool for the accurate quantification and study of metabolic pathways and exposure biomarkers. This high-purity compound is vital for laboratories in the pharmaceutical, contract research organization (CRO), and public health sectors that require reliable standards for method development and validation.

Application

• Analytical Reference Standard: Primary use as a certified standard for HPLC, LC-MS, and GC-MS analysis in method development and validation.
• Toxicology and Biomarker Research: Critical for studying the metabolism, bioactivation, and excretion profiles of specific nitrosamine compounds.
• Pharmaceutical Impurity Testing: Employed in the identification and quantification of potential nitrosamine-related impurities in active pharmaceutical ingredients (APIs) and drug products to ensure compliance with stringent regulatory limits (e.g., ICH M7).
• Environmental and Food Safety Analysis: Used in research to detect and measure exposure biomarkers in biological and environmental samples.
• Clinical Research: Supports studies investigating human exposure and metabolic handling of specific environmental contaminants.
• Forensic Science: Applied in specialized forensic toxicology analyses for definitive compound identification.

Basic Information

Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanyl α-D-Glucuronide
CAS No.	131119-04-5
Molecular Formula	C₁₇H₂₃N₃O₈
Molecular Weight	397.38 g/mol
Synonyms	NNAL-Glucuronide; NNAL-O-Glucuronide; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Glucuronide; (S)-NNAL-Gluc; NNAL Glucuronide (alpha isomer); N-Nitrosonornicotine metabolite glucuronide; 1-(3-Pyridyl)-1-butanol, 4-(methylnitrosamino)-, β-D-glucopyranosiduronic acid; Glucuronide conjugate of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanyl α-D-Glucuronide is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the high standards required for analytical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.