Description

Suc-Ala-Ala-Pro-Arg-Pna is a chromogenic peptide substrate designed for the specific and sensitive detection of serine protease activity. This compound is a critical reagent in biochemical research and diagnostic development, enabling precise enzymatic quantification. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for enzyme kinetics studies and assay development.

Application

• Enzyme Kinetics Research: Used as a selective substrate for studying the activity and inhibition kinetics of serine proteases like trypsin, thrombin, and related enzymes.
• Diagnostic Assay Development: Serves as a key component in developing colorimetric or fluorometric diagnostic tests for detecting protease levels in clinical samples.
• Pharmaceutical QC Testing: Employed in quality control protocols to measure the potency and consistency of enzyme-based biopharmaceuticals.
• High-Throughput Screening (HTS): Ideal for use in automated HTS platforms to identify novel protease inhibitors or activators for drug discovery.
• Biochemical Pathway Analysis: Facilitates the study of proteolytic cascades in physiological and pathological processes, such as blood coagulation or inflammation.
• Academic Research: A standard tool in university and institutional labs for teaching and investigating fundamental principles of enzymology.

Basic Information

Product Name	Suc-Ala-Ala-Pro-Arg-Pna
CAS No.	131068-47-8
Molecular Formula	C30H45N9O9
Molecular Weight	675.74 g/mol
Synonyms	Suc-AAPR-pNA; N-Succinyl-Ala-Ala-Pro-Arg p-Nitroanilide; Suc-AAPR-pNA; Succinyl-Alanine-Alanine-Proline-Arginine p-Nitroanilide; Chromogenic Substrate for Serine Proteases; Trypsin Substrate Suc-AAPR-pNA; Thrombin Substrate; Protease Substrate 131068-47-8
EINECS	Contact for details

Quality Control

Every batch of Suc-Ala-Ala-Pro-Arg-Pna is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistent performance. Our quality commitment includes comprehensive characterization by HPLC, MS, and NMR to verify identity and purity. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting research reproducibility and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	Tested for suitability as a protease substrate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.