Description

Allo-Tetrahydrocortisol 21-Glucuronide is a significant conjugated metabolite of cortisol, formed via the tetrahydro pathway and subsequent glucuronidation. This compound is crucial for research and development in endocrinology and clinical diagnostics, serving as a key reference standard for the accurate quantification of steroid hormone metabolites. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of in-vitro diagnostic (IVD) kits for hormone analysis.

Application

• Reference Standard for Clinical Diagnostics: Used as a high-purity calibrator and control material in LC-MS/MS and GC-MS assays for steroid profiling.
• Endocrinology Research: Essential for studying cortisol metabolism, enzyme activity (e.g., 5α/5β-reductase, UDP-glucuronosyltransferases), and related metabolic disorders.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetic (DMPK) studies to investigate the metabolic fate of corticosteroid-based therapeutics.
• In-Vitro Diagnostic (IVD) Manufacturing: A critical raw material for the production of immunoassays and chromatography-based test kits designed to measure urinary free cortisol and its metabolites.
• Biomarker Discovery & Validation: Used in metabolomics studies to identify and validate biomarkers associated with adrenal function, stress response, and Cushing's syndrome.
• Quality Control in Testing Laboratories: Serves as an internal standard to ensure the accuracy, precision, and reproducibility of analytical methods in clinical and forensic toxicology.

Basic Information

Item	Detail
Product Name	Allo-Tetrahydrocortisol 21-Glucuronide
CAS No.	131061-62-6
Molecular Formula	C27H40O12
Molecular Weight	556.60 g/mol
Synonyms	Allo-THF-21-Glucuronide; 3α,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one 21-β-D-Glucopyranosiduronic Acid; 5α-Tetrahydrocortisol 21-Glucuronide; (5α)-3α,11β,17α,21-Tetrahydroxypregnan-20-one 21-β-D-Glucuronide; ATHF-21-G; Urocortisol Glucuronide; Cortisol Metabolite Glucuronide; 5α-THF-21-G
EINECS	Contact for details

Quality Control

Our Allo-Tetrahydrocortisol 21-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.