Description

2-o-Oleoyl-1-Chloro-1-Deoxy-3-Phosphatidylcholine is a synthetic, chemically modified phospholipid derivative, specifically a chlorinated phosphatidylcholine analog. This compound is of significant interest for its role as a key intermediate and building block in advanced lipid research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for the synthesis of novel lipid-based drug delivery systems, membrane studies, and as a precursor for more complex bioactive lipids.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel phospholipid-based active pharmaceutical ingredients (APIs) and prodrugs.
• Lipid Nanoparticle (LNP) Research: Used in the development and optimization of next-generation lipid nanoparticles for mRNA and gene therapy delivery systems.
• Membrane Biophysics: Serves as a specialized component in model membrane studies to investigate lipid-protein interactions and membrane fluidity.
• Synthetic Chemistry: Acts as a versatile building block for the chemical modification and creation of custom phospholipids with tailored properties.
• Drug Delivery Vehicle Development: Employed in formulating liposomes and other vesicular carriers to enhance drug solubility, stability, and targeted release.
• Biochemical Probes: Can be functionalized to create labeled phospholipids for tracking and imaging applications in cellular assays.

Basic Information

Item	Detail
Product Name	2-o-Oleoyl-1-Chloro-1-Deoxy-3-Phosphatidylcholine
CAS No.	131024-86-7
Molecular Formula	C44H85ClNO7P
Molecular Weight	806.57 g/mol
Synonyms	1-Chloro-2-oleoyl-sn-glycero-3-phosphocholine; 1-Chloro-2-oleoyl-GPC; Chlorinated LysoPC-Oleoyl; 1-Chloro-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; 2-Oleoyl-1-chloro-1-deoxyphosphatidylcholine; 1-Chloro-2-oleoylphosphatidylcholine; (2R)-2-[[(2R)-3-Chloro-2-[(Z)-octadec-9-enoyloxy]propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
EINECS	Contact for details

Quality Control

Our 2-o-Oleoyl-1-Chloro-1-Deoxy-3-Phosphatidylcholine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic and moisture-sensitive; ensure containers are sealed and allowed to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.