Description

(R)-Di-2-Naphthylprolinol CAS NO 130798-48-0 is a high-value, chiral organocatalyst derived from proline, featuring two bulky 2-naphthyl groups. This structural configuration makes it a highly effective and selective ligand or catalyst for asymmetric synthesis, a cornerstone of modern pharmaceutical and fine chemical manufacturing. It is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in reactions such as aldol additions, Michael additions, and other carbon-carbon bond-forming processes.

Application

• Asymmetric Organocatalysis: As a key chiral catalyst for enantioselective aldol, Mannich, and Michael reactions in pharmaceutical intermediate synthesis.
• Chiral Ligand for Metal Complexes: Used to create chiral metal complexes for asymmetric hydrogenation and other transition metal-catalyzed transformations.
• Pharmaceutical Research & Development: Critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Synthesis: Employed in the production of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process chemistry optimization.
• Fine Chemical Production: For the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(R)-Di-2-Naphthylprolinol
CAS No.	130798-48-0
Molecular Formula	C₂₅H₂₁NO
Molecular Weight	351.44 g/mol
Synonyms	(R)-(-)-2,2'-Bis(di-2-naphthylhydroxymethyl)-1,1'-binaphthyl; (R)-2,2'-Di(naphthalen-2-yl)-1-((S)-pyrrolidin-2-yl)ethanol; (R)-α,α-Bis(2-naphthyl)-2-pyrrolidinemethanol; (R)-Di-2-naphthyl(2-pyrrolidinyl)methanol; (R)-Diprolinol; (R)-DINOL; (R)-DNP; (R)-Di(2-naphthyl)prolinol
EINECS	Contact for details

Quality Control

Our (R)-Di-2-Naphthylprolinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and IR for structural confirmation, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.