Description

Fmoc-Arg(Mtr)-Opfp is a specialized, high-purity amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled and efficient incorporation of arginine residues into peptide chains, offering enhanced stability and coupling efficiency. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in the synthesis of complex peptides, therapeutic proteins, and peptidomimetics for drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected arginine derivative for the automated and manual synthesis of custom peptides.
• Pharmaceutical Research & Development: For the production of peptide-based drug candidates, hormones, and enzyme inhibitors.
• Bioconjugation: Used in the site-specific modification of proteins and other biomolecules.
• Combinatorial Chemistry: A vital reagent in the generation of diverse peptide libraries for high-throughput screening.
• Academic Research: Employed in biochemical and structural biology studies investigating protein-protein interactions and function.
• Production of Biologically Active Peptides: Synthesis of antimicrobial peptides (AMPs), cell-penetrating peptides, and diagnostic agents.

Basic Information

Product Name	Fmoc-Arg(Mtr)-Opfp
CAS No.	130397-19-2
Molecular Formula	C₃₃H₃₃F₅N₆O₇S
Molecular Weight	752.71 g/mol
Synonyms	Fmoc-Arg(Mtr)-OPfp; Nα-Fmoc-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine pentafluorophenyl ester; Fmoc-L-arginine(Mtr)-OPfp ester; Fmoc-Arg(Mts)-OPfp; 9-Fluorenylmethyloxycarbonyl-Arg(Mtr)-Opfp; Fmoc-Arg(Mtr)-O-Pfp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nω-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-L-arginine 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Mtr)-Opfp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.