Description

5-Deaza-5,6,7,8-Tetrahydroisofolic Acid is a specialized heterocyclic compound belonging to the class of folate analogs. This compound is of significant interest in biochemical and pharmaceutical research due to its structural similarity to folic acid, making it a valuable intermediate and tool for studying enzyme mechanisms and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic agents, and biochemical probes. The product is supplied with a high level of purity to meet the stringent requirements of advanced research and development applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates targeting folate-dependent enzymes.
• Biochemical Research: Used as a research tool to study enzyme inhibition, particularly for dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Diagnostic Agent Development: Investigated for potential use in the development of diagnostic assays and imaging agents.
• Academic Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry and biochemistry.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	5-Deaza-5,6,7,8-Tetrahydroisofolic Acid
CAS No.	130327-70-7
Molecular Formula	C19H21N7O6
Molecular Weight	443.42 g/mol
Synonyms	5-Deaza-5,6,7,8-tetrahydrofolic acid; 5-Deaza-THF; Isofolic acid analog; 5-Deaza-5,6,7,8-tetrahydropteroylglutamic acid; NSC 339313; 5-DTHFA; Tetrahydro-5-deazafolic acid; 5,6,7,8-Tetrahydro-5-deazapteroylglutamic acid
EINECS	Contact for details

Quality Control

Our 5-Deaza-5,6,7,8-Tetrahydroisofolic Acid is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system is designed to support research and development needs where reliability and traceability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.