Description

Hoe 140 is a potent and selective bradykinin B2 receptor antagonist, a critical research tool in pharmacology and biochemistry. This compound is essential for studying the role of the kallikrein-kinin system in physiological and pathological processes, including inflammation, pain, and cardiovascular regulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in drug discovery and mechanistic studies.

Application

• Pharmacological Research: A standard tool for investigating the physiological roles of bradykinin and its receptors in various disease models.
• Inflammation Studies: Used to elucidate the involvement of the kinin system in inflammatory responses, edema, and pain pathways.
• Cardiovascular Research: Applied in studies focusing on blood pressure regulation, vascular permeability, and heart function.
• Neuropharmacology: Employed to study the effects of bradykinin in the central and peripheral nervous systems.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the development of novel B2 receptor antagonists.
• In Vitro & In Vivo Assays: Used in receptor binding studies, functional cellular assays, and animal model experiments.

Basic Information

Product Name	Hoe 140
CAS No.	130308-48-4
Molecular Formula	C₄₅H₆₈N₁₄O₁₁S₂
Molecular Weight	1021.23 g/mol
Synonyms	Icatibant; D-Arg-[Hyp³, Thi⁵, D-Tic⁷, Oic⁸]-Bradykinin; HOE-140; JE 049; B2 Receptor Antagonist; Bradykinin B2 Antagonist; (R)-1-[[2,3-Dihydro-1-oxo-1H-1-isoindolyl]carbonyl]-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-arginine
EINECS	Contact for details

Quality Control

Our Hoe 140 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Biological Activity	Assayed (IC50 provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.