Description

C8-(N2-Aminofluorenyl)Deoxyguanosine-3',5'-Diphosphate is a modified deoxyguanosine nucleotide bearing a C8-linked N2-aminofluorenyl adduct, a structure of significant interest in biochemical and toxicological research. This compound serves as a critical reference standard and synthetic intermediate for studying DNA damage and mutagenesis caused by aromatic amine carcinogens. It is primarily utilized by research institutions, pharmaceutical R&D departments, and analytical laboratories focused on genetic toxicology, biomarker discovery, and the development of detection methods for DNA adducts.

Application

• DNA Adduct Research: Used as a stable, well-characterized standard for the identification and quantification of specific DNA lesions formed by aromatic amines.
• Biomarker Development: Serves as a key material in the development of analytical assays (e.g., HPLC-MS/MS, 32P-postlabeling) to detect exposure to environmental carcinogens.
• Mutagenesis Studies: Employed to investigate the structural and functional consequences of specific DNA damage on replication fidelity and repair mechanisms.
• Enzymology: Used as a substrate to study the activity and specificity of DNA repair enzymes, such as glycosylases and nucleotidyl transferases.
• Synthetic Chemistry: Acts as a sophisticated building block for the chemical synthesis of oligonucleotides containing site-specific lesions for advanced biophysical studies.
• Toxicology & Safety Assessment: Provides a critical tool for in vitro and in vivo studies assessing the genotoxic potential of chemicals and their metabolic activation pathways.

Basic Information

Product Name	C8-(N2-Aminofluorenyl)Deoxyguanosine-3',5'-Diphosphate
CAS No.	130281-89-9
Molecular Formula	C₂₈H₂₉N₈O₁₂P₂
Molecular Weight	731.52 g/mol
Synonyms	N-(Deoxyguanosin-8-yl)-2-aminofluorene-3',5'-diphosphate; 8-(N2-Aminofluorenyl)-2'-deoxyguanosine-3',5'-diphosphate; C8-AF-dG-3',5'-diphosphate; AF-dGpp; 2-Aminofluorene-C8-deoxyguanosine diphosphate; DNA adduct standard (C8-AF-dG); N-(Guan-8-yl)-2-AF-3',5'-diphosphate
EINECS	Contact for details

Quality Control

Our C8-(N2-Aminofluorenyl)Deoxyguanosine-3',5'-Diphosphate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and analytical data is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.