Description

n-Succinimidyl-2,4-Dimethoxy-3-Iodobenzoate is a highly reactive, heterobifunctional crosslinking reagent designed for the site-specific modification of biomolecules. This compound matters for its ability to introduce a stable, iodinated aromatic moiety into peptides, proteins, or other amine-containing compounds, facilitating downstream applications in labeling, detection, and conjugation. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs) and diagnostic imaging agents.

Application

• Bioconjugation Reagent: For the covalent attachment of fluorescent dyes, biotin, or other probes to primary amines (-NH2) on proteins and peptides.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key linker-payload intermediate for attaching cytotoxic drugs to monoclonal antibodies.
• Proteomics Research: Used in the preparation of affinity tags or isotopic labeling reagents for mass spectrometry-based protein analysis.
• Diagnostic Agent Development: Facilitates the radiolabeling (e.g., with I-125) of targeting molecules for in vitro and in vivo imaging.
• Surface Functionalization: Enables the modification of amine-coated surfaces, beads, or chips for biosensor and microarray applications.
• Polymer Chemistry: Acts as an activating agent for introducing functional groups into polymer backbones or dendrimers.

Basic Information

Product Name	n-Succinimidyl-2,4-Dimethoxy-3-Iodobenzoate
CAS No.	130168-14-8
Molecular Formula	C13H12INO6
Molecular Weight	405.14 g/mol
Synonyms	2,4-Dimethoxy-3-iodobenzoic Acid N-Hydroxysuccinimide Ester; 3-Iodo-2,4-dimethoxybenzoic Acid N-Succinimidyl Ester; SIDMB-OSu; NHS Ester of 2,4-Dimethoxy-3-iodobenzoic Acid; 2,4-Dimethoxy-3-iodobenzoic Acid, Succinimidyl Ester; N-(2,4-Dimethoxy-3-iodobenzoyloxy)succinimide; 130168-14-8
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-2,4-Dimethoxy-3-Iodobenzoate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We adhere to cGMP guidelines where applicable to support our customers in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed container with silica gel) due to its hygroscopic (moisture-sensitive) nature. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.