Description

Methotrexate-α-Arginine CAS NO 129921-89-7 is a chemically modified derivative of the established antifolate agent methotrexate, designed to enhance its pharmacological profile. This compound is significant for its potential to improve drug delivery and therapeutic efficacy in targeted medical applications. It is primarily required by pharmaceutical research and development organizations engaged in creating advanced oncology and autoimmune disease therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, targeted methotrexate prodrugs and conjugates.
• Oncology Research: Investigated for the development of chemotherapeutic agents with improved tumor selectivity and reduced systemic toxicity.
• Autoimmune Disease Research: Used in studies aimed at creating next-generation anti-inflammatory and immunosuppressive therapies.
• Drug Delivery System Development: Employed in the formulation of carrier-linked prodrugs to enhance solubility, stability, and cellular uptake.
• Biochemical Research: Utilized as a tool compound in studies of folate metabolism and enzyme inhibition mechanisms.
• Preclinical Development: Supports pharmacokinetic, pharmacodynamic, and toxicology studies for new chemical entities.

Basic Information

Product Name	Methotrexate-α-Arginine
CAS No.	129921-89-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MTX-α-Arg; Methotrexate L-Arginine Salt; Methotrexate Arginine Derivative; N-(4-{(2,4-Diaminopteridin-6-yl)methylamino}benzoyl)-L-arginine; L-Arginine, N2-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; Methotrexate-Arg Conjugate
EINECS	Contact for details

Quality Control

Our Methotrexate-α-Arginine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.