Description

8-(4-Chlorophenylthio)Adenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a high-purity, biologically active analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical and pharmacological research. This compound serves as a potent and selective inhibitor of cAMP-dependent protein kinase (PKA), making it an essential tool for elucidating signal transduction pathways. It is primarily utilized by researchers and developers in the fields of cell biology, neuroscience, and drug discovery to study cellular regulation and develop novel therapeutic agents.

Application

• Biochemical Research: As a cell-permeable, Rp-isomer-specific inhibitor of Protein Kinase A (PKA) for studying cAMP-mediated signaling cascades.
• Neuroscience Studies: Investigation of synaptic plasticity, neurotransmitter release, and long-term potentiation (LTP) mechanisms in neuronal cells.
• Cardiovascular Research: Exploration of cardiac muscle contraction, ion channel regulation, and the role of PKA in heart function.
• Drug Discovery & Development: A key reference standard and pharmacological tool for screening and validating new compounds targeting the PKA pathway.
• Cellular Physiology: Studies on hormone action, metabolism, gene expression, and cell cycle progression controlled by cAMP levels.
• Academic & Institutional Labs: Fundamental research in university and government laboratories focused on molecular biology and intracellular communication.

Basic Information

Product Name	8-(4-Chlorophenylthio)Adenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	129735-01-9
Molecular Formula	C16H15ClN5O5PS2Na
Molecular Weight	527.86 g/mol
Synonyms	Rp-8-(4-Chlorophenylthio)-cAMPS Sodium Salt; Rp-8-CPT-cAMPS Sodium Salt; Adenosine 3',5'-cyclic monophosphorothioate, 8-[(4-chlorophenyl)thio]-, Rp-isomer, sodium salt; cAMP antagonist Rp-isomer; Protein Kinase A Inhibitor (Rp-isomer); 8-CPT-cAMPS, Rp-isomer, sodium salt; RP-CPT-CAMPS NA SALT
EINECS	Contact for details

Quality Control

Our production of this high-grade biochemical is governed by a stringent quality management system. Every batch is subjected to comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS), to ensure consistency and biological activity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our rigorous specifications for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.