Description

8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified, non-hydrolyzable analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical research. This compound is critically important as a potent and selective antagonist of cAMP-dependent protein kinase (PKA), enabling precise manipulation of intracellular signaling pathways. It is primarily needed by researchers and developers in the fields of cell biology, neuroscience, and pharmacology for investigating signal transduction mechanisms and developing targeted therapeutic strategies.

Application

• Biochemical Research: As a potent and specific inhibitor of Protein Kinase A (PKA) to study cAMP-mediated signaling cascades.
• Neuroscience Studies: Investigation of synaptic plasticity, neurotransmitter release, and neuronal excitability regulated by PKA.
• Cardiovascular Research: Exploration of cardiac contractility and ion channel modulation where cAMP-PKA pathways are involved.
• Cell Signaling Pathway Analysis: Used in cell-based assays to dissect the role of PKA in growth, differentiation, and apoptosis.
• Drug Discovery & Development: A key tool compound for validating PKA as a therapeutic target and screening for novel inhibitors.
• Metabolic Disorder Research: Studying the regulation of glycogen, sugar, and lipid metabolism via PKA inhibition.

Basic Information

Product Name	8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	129735-00-8
Molecular Formula	C10H10BrN5O5PS2Na
Molecular Weight	513.31 g/mol
Synonyms	8-Br-cAMPS, Rp-isomer sodium salt; Rp-8-Bromo-cAMPS; Rp-8-Br-adenosine-3',5'-cyclic monophosphorothioate sodium salt; cAMP antagonist, Rp-8-Bromo; Protein Kinase A Inhibitor, Rp-8-Br-cAMPS; 8-Bromo-cyclic adenosine monophosphorothioate, Rp isomer; 8-Br-cyclic AMP thioate, Rp-isomer; Rp-8-Bromo-cyclic adenosine 3',5'-monophosphorothioate
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous quality testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.