Description

8-(4-Chlorophenylthio) Adenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a high-purity, biologically active analog of cyclic adenosine monophosphate (cAMP) designed for advanced life science research. This compound is specifically engineered to be resistant to hydrolysis by phosphodiesterases, making it a crucial tool for the sustained activation of protein kinase A (PKA) and related signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in signal transduction studies, drug discovery for metabolic and cardiovascular diseases, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a potent and hydrolysis-resistant activator of Protein Kinase A (PKA) for studying cAMP-mediated signal transduction pathways.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify and validate new drug candidates targeting PKA and related enzymes.
• Cellular Physiology Studies: Investigation of cellular processes such as gene expression, metabolism, ion channel function, and cardiac contractility.
• Neuroscience Research: Exploring the role of cAMP and PKA in neuronal plasticity, memory formation, and neurotransmitter release.
• Metabolic Disorder Research: A key reagent in studies focused on diabetes, obesity, and hormonal regulation.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	8-(4-Chlorophenylthio) Adenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	129693-13-6
Molecular Formula	C16H14ClN5O5PS2•Na
Molecular Weight	529.85 g/mol
Synonyms	8-(p-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, Sp-isomer, sodium salt; 8-CPT-cAMPS, Sp-isomer, sodium salt; Sp-8-(4-Chlorophenylthio)-cAMPS sodium salt; Sp-8-CPT-cAMPS sodium salt; Protein Kinase A Activator (Sp-isomer); cAMP analog, Sp-isomer; Adenosine 3',5'-cyclic monophosphorothioate, 8-(4-chlorophenylthio)-, Sp-isomer, sodium salt
EINECS	Contact for details

Quality Control

Our 8-(4-Chlorophenylthio) Adenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.