Description

Oxythiamine Disulfide Monosulfoxide is a chemically modified derivative of thiamine (Vitamin B1) with distinct biochemical properties. This compound is of significant interest in advanced research for its role as a potent and specific antagonist of thiamine-dependent enzymes, making it a valuable tool for studying metabolic pathways. It is primarily utilized by research institutions and pharmaceutical developers in the fields of biochemistry, enzymology, and metabolic disease research.

Application

• Biochemical Research: As a specific inhibitor of thiamine pyrophosphate (TPP)-dependent enzymes like transketolase and pyruvate dehydrogenase for mechanistic studies.
• Metabolic Pathway Analysis: Used to induce experimental thiamine deficiency models to investigate related metabolic disorders and cellular energy metabolism.
• Pharmaceutical R&D: Serves as a reference standard or an intermediate in the development of novel therapeutic agents targeting thiamine metabolism.
• Enzymology Studies: A key tool compound for probing the active sites and catalytic mechanisms of thiamine-utilizing enzymes.
• Nutritional Science Research: Employed in studies examining the absorption, transport, and antagonism of B-vitamins at the molecular level.

Basic Information

Item	Detail
Product Name	Oxythiamine Disulfide Monosulfoxide
CAS No.	129228-57-5
Molecular Formula	C₁₂H₁₆N₄O₃S₂
Molecular Weight	328.41 g/mol
Synonyms	Oxythiamine Disulfide S-Monoxide; Thiamine Disulfide Monoxide Derivative; Vitamin B1 Antagonist; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-[[[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]ethyl]disulfinyl)methyl]-4-methylthiazolium Salt; Oxythiamine S-Oxide Disulfide; Thiamine Disulfide Monoxide
EINECS	Contact for details

Quality Control

Our Oxythiamine Disulfide Monosulfoxide is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.