Description

Glutathionylcobalamin is a unique organometallic compound that serves as a key intermediate in mammalian cobalamin metabolism. This compound matters for its role in the intracellular processing of vitamin B12, facilitating its conversion into the active coenzyme forms, methylcobalamin and adenosylcobalamin. It is primarily needed by researchers in biochemistry and pharmaceutical development, as well as manufacturers focused on advanced nutraceutical and diagnostic reagent production. Glutathionylcobalamin CAS NO 129128-04-7 represents a critical tool for studying B12-dependent enzymatic pathways and related disorders.

Application

• Biochemical Research: Used as a critical standard and reagent for studying the intracellular metabolism and trafficking of vitamin B12 (cobalamin).
• Enzyme Mechanism Studies: Essential for investigating the function of cobalamin-processing enzymes like CblC (MMACHC) and for modeling inborn errors of metabolism.
• Pharmaceutical Reference Standard: Serves as a high-purity reference material for analytical method development and quality control in drug discovery related to B12 therapies.
• Nutraceutical Development: Investigated for potential applications in advanced vitamin B12 supplement formulations with targeted bioavailability.
• Diagnostic Reagent Manufacturing: Utilized in the production of specialized reagents for clinical assays that measure cobalamin and related metabolites.

Basic Information

Product Name	Glutathionylcobalamin
CAS No.	129128-04-7
Molecular Formula	C72H105CoN18O21S2
Molecular Weight	~1682.8 g/mol
Synonyms	Cob(II)alamin-glutathione complex; Glutathionylcob(III)alamin; Cobalamin-glutathione conjugate; Vitamin B12-glutathione adduct; GS-Cbl; γ-Glutamylcysteinylglycylcobalamin; B12 intermediate with glutathione; Cobalamin bound to glutathione
EINECS	Contact for details

Quality Control

Our Glutathionylcobalamin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, UV-Vis spectroscopy, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive (protect from all light exposure). For long-term stability, store frozen at -20°C or below under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Dark red to brown solid or solution
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Spectrum matches characteristic profile
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Content (Residual)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.