Description

Suc-Ala-Ala-Val-Amc CAS NO 128972-90-7 is a specialized fluorogenic peptide substrate designed for the sensitive detection and quantification of elastase and related serine protease activity. This compound is critical for researchers and quality control labs requiring precise enzymatic assays. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit manufacturing for studying inflammatory diseases and protease inhibitor screening.

Application

• Enzymatic Assay Substrate: Primary substrate for human leukocyte elastase (HLE), porcine pancreatic elastase, and related serine proteases in kinetic and endpoint assays.
• Pharmaceutical Research: High-throughput screening (HTS) for the discovery and evaluation of novel elastase inhibitors as potential therapeutics for COPD, cystic fibrosis, and ARDS.
• Diagnostic Development: Key component in fluorometric diagnostic kits and reagents for measuring elastase activity in clinical and research samples.
• Biochemical Research: Tool for studying protease signaling pathways, enzyme kinetics, and protein degradation mechanisms in vitro.
• Quality Control: Used in QC laboratories for potency testing of biopharmaceuticals where elastase activity is a critical quality attribute.

Basic Information

Product Name	Suc-Ala-Ala-Val-Amc
CAS No.	128972-90-7
Molecular Formula	C₂₀H₃₀N₄O₇
Molecular Weight	438.48 g/mol
Synonyms	Suc-A-A-V-AMC; Suc-Ala-Ala-Val-7-amido-4-methylcoumarin; N-Succinyl-Ala-Ala-Val-7-amido-4-methylcoumarin; N-Succinyl-L-alanyl-L-alanyl-L-valyl-7-amido-4-methylcoumarin; Elastase Substrate IV; Fluorogenic Elastase Substrate; SAAV-AMC; Suc-AAV-AMC
EINECS	Contact for details

Quality Control

Our Suc-Ala-Ala-Val-Amc is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot undergoes comprehensive analysis including HPLC purity verification, mass spectrometry (MS) confirmation, and functional activity testing. Certificates of Analysis (COA) detailing purity, identity, and assay performance are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Functional Activity	≥ 90% relative activity vs. reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.