Description

Pybop CAS NO 128625-52-5 is a high-purity peptide coupling reagent widely used in solid-phase peptide synthesis (SPPS). This compound is critical for facilitating efficient amide bond formation, a fundamental step in constructing complex peptides and proteins. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing novel therapeutic peptides, APIs, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a highly effective coupling reagent for the synthesis of peptides, including difficult sequences.
• Pharmaceutical Intermediates: Production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic disorders, oncology, and CNS diseases.
• Bioconjugation: Facilitating the coupling of peptides to carrier proteins, polymers, or surfaces for drug delivery systems and diagnostic assays.
• Combinatorial Chemistry: Used in high-throughput synthesis for generating peptide libraries for drug discovery and screening.
• Academic & Industrial Research: A standard reagent in R&D laboratories for studying protein structure-function relationships and developing new synthetic methodologies.
• Production of Protected Amino Acid Derivatives: For the preparation of advanced intermediates used in fragment condensation strategies.

Basic Information

Product Name	Pybop
CAS No.	128625-52-5
Molecular Formula	C18H28F6N6OP+ • PF6-
Molecular Weight	649.37 g/mol
Synonyms	Benzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate; (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; PyBOP® Reagent; 1H-1,2,3-Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate; PyBOP coupling reagent; Phosphonium, (1H-benzotriazol-1-yloxy)tris[1-pyrrolidinyl]-, hexafluorophosphate(1-); CAS 128625-52-5
EINECS	Contact for details

Quality Control

Our Pybop is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance in sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.